In calichearubicin B (1) the aglycon of daunorubicin and the carbohydrate domain of calicheamicin γ are linked by a spacer (calichearubicin A lacks this spacer). The aglycone serves as an anthracycline-like intercalator, while the carbohydrate portion binds to the minor groove of DNA. Thus calichearubicin B exhibits properties of both parent compounds.
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Depew et al. (1996) studied this question.
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