Why the study?
Do spontaneous changes in heart rate and rhythm affect the contractile force of the isovolumic left ventricle in dogs?
Do spontaneous changes in heart rate and rhythm affect the contractile force of the isovolumic left ventricle in dogs?
In an intact mammalian heart model, changes in heart rate and rhythm directly alter ventricular contractile force independent of muscle fiber length (Frank-Starling mechanism).
No takes yet. Share an insight, caveat, or question.
Supports intrinsic contractility modulation by rate/rhythm; leaves open human translation.
Lendrum et al. (1960) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: