May 1, 2001AJP Heart and Circulatory Physiology
Progressive loss of perfusion-contraction matching during sustained moderate ischemia in pigs
Key result
Prolonged myocardial hypoperfusion for up to 24 hours in pigs resulted in a progressive loss of perfusion-contraction matching, with work index decreasing to 18% of baseline despite unchanged blood flow.
Population
27 anesthetized pigs
Comparison
Sustained moderate ischemia vs Baseline (prior to hypoperfusion)
Design
Preclinical
Follow-up
Up to 24 hours
Authors
Discussion
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Member takes
Implication
Extends perfusion-contraction matching observations to 24-hour hypoperfusion in pigs; leaves open relevance to human chronic ischemia.
Structured PICO
P
Population
27 anesthetized pigs
I
Intervention
Sustained moderate ischemia (reduction of left anterior descending coronary arterial inflow to decrease anterior work index by 40% at 5 min, maintained for 12 or 24 h)
C
Comparator
Baseline (prior to hypoperfusion)
O
Outcome
Perfusion-contraction matching (relationship between work index and transmural blood flow) and calcium responsivenesssurrogate
Prolonged moderate ischemia in a pig model leads to a progressive loss of perfusion-contraction matching and reduced calcium responsiveness.
Cite This Study
Schulz et al. (2001) studied Myocardial ischemia (n=27). Prolonged hypoperfusion vs. Baseline / 5 min hypoperfusion was evaluated on Perfusion-contraction matching (work index and transmural blood flow). Prolonged myocardial hypoperfusion for up to 24 hours in pigs resulted in a progressive loss of perfusion-contraction matching, with work index decreasing to 18% of baseline despite unchanged blood flow.