What does this research mean for the field?

In patients with cardiac failure following acute myocardial infarction, dobutamine significantly improves hemodynamics by increasing cardiac output and decreasing filling pressure, whereas digoxin has minimal effects on preload, afterload, or cardiac index. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 9, 1980New England Journal of Medicine

A Comparison of Digoxin and Dobutamine in Patients with Acute Infarction and Cardiac Failure

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Why the study?

Does dobutamine improve hemodynamics compared to digoxin in patients with cardiac failure complicating acute myocardial infarction?

Population

6 patients with cardiac failure within 24 hours of onset of acute myocardial infarction

Comparison

Dobutamine given intravenously for 30 minutes vs Digoxin given intravenously

Design

Case_series

Follow-up

120 minutes

Authors

RGRichard A. GoldsteinUniversity College London EPEugene R. PassamaniCosmos Corporation (United States)RRRobert RobertsBrigham Young University

Discussion

Member takes

Implication

Dobutamine may aid acute hemodynamics in post-MI failure; this case report leaves open any superiority versus digoxin.

Structured PICO

Does dobutamine improve hemodynamics compared to digoxin in patients with cardiac failure complicating acute myocardial infarction?

Population

6 patients with cardiac failure within 24 hours of onset of acute myocardial infarction

Intervention

Dobutamine (8.5 microgram per kilogram of body weight per minute) given intravenously for 30 minutes

Comparator

Digoxin (12.5 microgram per kilogram) given intravenously (administered sequentially after dobutamine washout)

Outcome

Hemodynamic effects including left ventricular filling pressure, systemic vascular resistance, cardiac index, and stroke work indexsurrogate

In patients with heart failure complicating acute myocardial infarction, dobutamine provides superior acute hemodynamic benefits compared to digoxin by increasing cardiac output and reducing filling pressures.

Cite This Study

Goldstein et al. (1980) studied this question.

synapsesocial.com/papers/6a1d643932d43530c25da7d2 https://doi.org/10.1056/nejm198010093031503

Topics

Heart failure HFrEF treatment

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A Comparison of Digoxin and Dobutamine in Patients with Acute Infarction and Cardiac Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

A Comparison of Digoxin and Dobutamine in Patients with Acute Infarction and Cardiac Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider