Key result
IV morphine induces rapid vasodilation followed by delayed cardiosuppression and prolonged ventricular repolarization in vivo.
Why the study?
Morphine is used for treatment-resistant dyspnea in end-stage heart failure, but information regarding its cardiovascular safety profile remains limited.
Does intravenous morphine alter cardiohemodynamic and electrophysiological parameters in halothane-anesthetized dogs?
Does intravenous morphine alter cardiohemodynamic and electrophysiological parameters in halothane-anesthetized dogs?
Intravenous morphine causes rapid vasodilation and delayed cardiosuppression with QT prolongation in a canine model, suggesting a risk of distributive shock at high doses but a low risk of torsade de pointes.
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Suggests hemodynamic risks with high-dose IV morphine in anesthetized models; leaves open translation to clinical practice.
Goto et al. (2024) studied Healthy (animal model) (n=4). Morphine hydrochloride hydrate vs. Pre-drug basal control was evaluated. Intravenously administered morphine exerts a rapidly appearing vasodilator action followed by slowly developing cardiosuppressive effects, and can delay ventricular repolarization in vivo.
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