Why the study?
Does the lowering of cholesterol or low serum cholesterol concentration increase the risk of mood disorders, impulse control disorders, and mortality due to suicide, homicide, or accidents?
Does the lowering of cholesterol or low serum cholesterol concentration increase the risk of mood disorders, impulse control disorders, and mortality due to suicide, homicide, or accidents?
This review highlights a potential safety concern regarding cholesterol lowering and low serum cholesterol, suggesting a possible link to adverse psychological outcomes and increased risk of suicide, homicide, and accidents.
May warrant monitoring for mood disorders with low cholesterol; leaves open causality and needs prospective trials before practice change.
This paper reviews the relationship between cholesterol and psychological functioning. Possibly a relationship exists between the lowering of cholesterol, low serum cholesterol concentration and mood and/or impulse control disorders. This might be associated with a disregulated cerebral serotonin metabolism. These hypotheses are based on (meta-analyses of) epidemiologic research investigating the lowering of cholesterol. One of the findings was an increased mortality due to suicide, homicide and accidents. Much is still unknown about the matters mentioned above. However, recommendations for research and clinical psychiatric practice are formulated.
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Duits et al. (1995) studied this question.
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