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January 1, 2017Journal of Hepatology and Gastrointestinal disordersOpen Access

Liver Injury due to Amoxicillin vs. Amoxicillin/Clavulanate: A Subgroup Analysis of a Drug-Induced Liver Injury Case-Control Study in Italy

Monia Donati Domenico Motola Roberto Leone Ugo Moretti Giovanna Stoppa Elena Arzenton M Lenti Roberto Bonaiuti Alessandro Mugelli Alfredo Vannacci Concetta Rafaniello Liberata Sportiello Annalisa Capuano Oscar Bortolami Alberto Vaccheri

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Abstract

Objective: Several studies showed that amoxicillin plus clavulanic acid (co-amoxiclav) is one of the most common agents associated to serious Drug Induced Liver Injury (DILI). We estimated the risk of acute serious DILI associated with amoxicillin alone compared with co-amoxiclav, through a multicenter case-control study carried out in nine Italian hospitals from October 2010 to January 2014.

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Donati et al. (2017) studied this question.

synapsesocial.com/papers/6a1d72765b7fddc352054cf6 https://doi.org/10.4172/2475-3181.1000143

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