Key result
Urban fine particulate air pollution exposure promotes atherosclerosis and lipid deposition in apolipoprotein E-deficient mice by activating inflammation via the Wnt5a/Ror2 pathway.
Why the study?
Does urban fine particulate air pollution exposure promote atherosclerosis in apolipoprotein E-deficient mice?
Does urban fine particulate air pollution exposure promote atherosclerosis in apolipoprotein E-deficient mice?
Urban fine particulate air pollution promotes atherosclerosis in ApoE-deficient mice via perivascular adipose tissue inflammation and Wnt5a/Ror2 signaling.
Supports mechanistic research on pollution in atherosclerosis models; leaves open human translation and intervention trials.
-induced atherosclerosis process, as well as lipid deposition, which was closely associated with the activation of the Wnt5a/Ror2 signaling pathway.
No takes yet. Share an insight, caveat, or question.
Wan et al. (2021) studied this question. Urban fine particulate air pollution exposure promotes atherosclerosis and lipid deposition in apolipoprotein E-deficient mice by activating inflammation via the Wnt5a/Ror2 pathway.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: