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Review details molecular mechanisms of cellular damage in ischemia–reperfusion injury, highlighting established and novel therapeutic approaches for tissue protection.
Abstract—Ischemia–reperfusion is a cascade of complex and interrelated pathological processes underlying many human diseases, including such socially significant diseases as stroke, myocardial infarction, acute renal failure, etc. The present review considers modern ideas about the main biochemical and signal-regulatory processes in the cell under conditions of ischemia–reperfusion. Both generally accepted and newly developed ways of ischemia–reperfusion lesion correction aimed at different chains of this pathological process are considered.
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Goncharov et al. (2023) studied this question.
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