Pathological study reveals marked cellular hyperplasia and severe hypofibrinaemia in acute premyelocytic leukaemia, highlighting a rapidly fatal course driven by abnormal granulated cells.
Among the acute leukaemias of the granulocytic group, acute premyelocytic leukaemia is distinguished by the severity of its haemorrhages, the frequency of hypofibrinaemia, a rapidly fatal course, and an unusual cellular hyperplasia. Myelograms show an increased proportion (average 80%) of characteristic cells of large diameter, with numerous azurophil granules. The infiltration of other organs is inconstant.
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Bernard et al. (1963) studied this question.
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