Basic science study showing that new myofibrillar proteins are added to the periphery of existing fibrils during postnatal muscle growth.
Answers are grounded in this paper and cite their sources.
Does not yet warrant clinical practice changes; extends mechanistic insights into postnatal myofibrillogenesis in animal models.
Addition of newly synthesized contractile proteins to striated muscle during postnatal life was studied by labeling young rat diaphragms in vitro with (3)H-leucine and extracting the soluble proteins in glycerol. The grain distribution over glycerinated fibers in electron microscopic autoradiographs indicates that new myofibrillar proteins are added about the periphery of existing fibrils.
No takes yet. Share an insight, caveat, or question.
Eugene Morkin (1970) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: