Efficacy of an online mindfulness program (MindOnLine) to reduce fear of recurrence in people living with–and beyond–breast, prostate or colorectal cancer: a randomized controlled trial

Background: , an online mindfulness program, for people living with-and beyond-breast, prostate or colorectal cancer, in reducing FCR, anxiety and depression. Methods: impact on the primary (FCRI total score) and secondary (anxiety (GAD-7), depression (PHQ-9)) outcomes. Findings: decreased the FCRI total score (-5.61, 95% CI -8.61, -2.61, p < 0.001); anxiety (-1.29 -2.15, -0.43, p = 0.003) and depression (-1.47 -2.34, -0.61, p < 0.001) scores, compared to the waitlist group. Intervention effects were sustained at 9-months (FCRI: -5.06 -8.61, -1.52; p = 0.005; anxiety: -1.22 -2.21, -0.24, p = 0.015; depression: -1.09 -2.03, -0.16, p = 0.022). Interpretation: Our findings demonstrate that a self-directed, brief, online mindfulness-based program mitigates moderate or severe fear of cancer recurrence. Further research is necessary to guide the development of future services, policies and practices by identifying how online mindfulness programs can be customized to effectively support diverse population groups, ensuring the programs are effective and accessible and impactful, regardless of their personal circumstances or geographical location. Funding: This study was funded by the National Health and Medical Research Council (NHMRC) Partnership Grant ID APP1179317, with partner cash contributions from the Department of Health, Victoria, Epworth HealthCare and Western Health.