Cutis Laxa Associated With Severe Intrauterine Growth Retardation and Congenital Dislocation of the Hip

Summary Two female siblings with cutis laxa are reported. Both these infants showed marked intrauterine growth retardation, hyperlaxity of the joints, with congenital dislocation of the hip. Four similar female infants have been reported in the literature. The mode of inheritance appears to be as an autosomal recessive gene. The marked degree of intrauterine growth retardation may be indicative of a more severe form of the disease, which might be lethal in the male foetus.