Key result
Beta-blockers and angiotensin II type I receptor blockers, particularly losartan, are recommended to slow aortic root dilatation and reduce cardiovascular complications in Marfan syndrome.
Why the study?
Advances in research have provided new insights into Marfan syndrome pathogenesis and opened up new treatment horizons, prompting an updated review of medical management.
This review highlights that beta-blockers and ARBs (particularly losartan) are the mainstays of medical therapy to slow aortic root dilatation and prevent cardiovascular events in Marfan syndrome.
Supports current recommendations for beta-blockers and ARBs in Marfan syndrome; leaves open optimal regimens from higher-level trials.
Marfan syndrome (MFS), a multisystemic connective disorder, caused by fibrillin 1 gene mutations with autosomal dominant inheritance. The disease spectrum is wide and the major causes of death are related to aortic root aneurysm or dissection. The purposes of medical treatment are to reduce structural changes in the aortic wall and slow aortic root dilatation. Advance in medical researches have provided new insights into the pathogenesis of disease and opened up new horizons for treatments. Several medications such as angiotensin II type I receptor blockers, β-blockers, angiotensin-converting enzyme inhibitors, calcium channel blockers, tetracyclines, and statins have been studied for the purpose. Currently, the life expectancy of Marfan patients improves significantly and is closes to the general population with proper treatment. In this article, we review and update the medical treatments for patients with MFS.
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Hsin–Hui Chiu (2021) conducted a review in Marfan syndrome. Pharmacological treatments (Beta-blockers, ARBs) was evaluated. Beta-blockers and angiotensin II type I receptor blockers, particularly losartan, are recommended to slow aortic root dilatation and reduce cardiovascular complications in Marfan syndrome.
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