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HIF-1α-mediated metabolic reprogramming toward glycolysis mitigates T cell exhaustion and augments cytotoxic persistence, offering a strategic approach to overcome the immunosuppressive microenvironment and enhance CAR-T cell efficacy in solid tumors. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

CAR-T cell therapy for solid tumors: HIF-1α as a potential enhancement strategy

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