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The short-chain fatty acid γ-hydroxybutyric acid (GHB), which is synthesized as an analogue of γ-aminobutyric acid (GABA) that would cross the blood–brain barrier, has found limited clinical use as an anesthetic agent and as treatment for narcolepsy and alcoholism. However, during the past decade, GHB has emerged as a major recreational drug in the United States. This review article discusses the mechanisms of action and presents an approach to the treatment of overdose, abuse, and addiction.
Snead et al. (Wed,) studied this question.
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