Omega-3 polyunsaturated fatty acid supplementation (2.4g daily) significantly improved the reactive hyperemia index from 1.62 to 1.96 (p<0.005) in patients with metabolic syndrome.
RCT (n=80)
Does omega-3 polyunsaturated fatty acid supplementation improve endothelial function in patients with metabolic syndrome?
Omega-3 polyunsaturated fatty acid supplementation for three months significantly improves endothelial function and arterial stiffness in patients with metabolic syndrome.
p-value: p=<0.005
Aim: Evaluation of role of supplementation of omega-3 polyunsaturated fatty acids on endothelial function in patients with metabolic syndrome. Methods: Total of 80 patients with metabolic syndrome were enrolled to two groups. We evaluated endothelial function in subjects before and after three-month treatment with omega-3 polyunsaturated fatty acids in dose 2.4g daily (800mg 3 times a day) vs placebo. Using the Endo-PAT2000 device (Itamar Medical Ltd. Caesarea, Israel), reactive hyperemia index – a parameter of endothelial function and augmentation index– a parameter of arterial stiffness were measured. Plasmatic level of glutation peroxidase, homocysteine, apolipoprotein B and lipoprotein (a) were also evaluated. Results: The average values of reactive hyperemia index before the treatment with n-3PUFA was 1.62 ± 0.42 , whereas 1.96 ± 0.62 at the end of the study (p0.005). Augmentation index changed from 14.66 ± 19.55 to 9.21 ± 15.64 after the treatment (p=0.003). We also observed statistically significant decrease of apolipopotein B (0.94 ± 0.36 vs 1.13 ± 0.35, p = 0.001) and homocysteine (19.31 ± 5.29 vs. 13.78 ± 3.05, p = 0.001) and increase of the glutathion perxidase plasma levels (41.65 ± 8.90 vs. 45.20 ± 8.01), p=0.001. Conclusion: We have observed significant improvement of the endothelial function in subjects with metabolic syndrome treated with omega-3 polyunsaturated fatty acids in dose 2.4g daily.
Jankajová et al. (Tue,) conducted a rct in Metabolic syndrome (n=80). Omega-3 polyunsaturated fatty acids vs. Placebo was evaluated on Reactive hyperemia index (p=<0.005). Omega-3 polyunsaturated fatty acid supplementation (2.4g daily) significantly improved the reactive hyperemia index from 1.62 to 1.96 (p<0.005) in patients with metabolic syndrome.