As a new class of stimulus-responsive surfactants, a series of α-methyl-ω-alkyl PEGs endowed with a carboxylic acid moiety at the hydrophobic terminal was successfully synthesized with 56–97% yields. They were characterized by IR, NMR spectroscopic and MALDI-TOF MS analyses. It is suggested by DLS measurement that the collapse of the micelle-like aggregation occurred under basic condition. This synthetic procedure would be applicable to surfactants with sufficient hydrophilic and lipophilic balances, allowing precise control of pH-responsive micellar systems.
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Morikawa et al. (2008) studied this question.
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