Key result
Population patch clamp electrophysiology offers greater speed and precision than existing methods for screening compounds at voltage-gated ion channel targets in drug discovery.
Population patch clamp is a promising high-throughput electrophysiology technique that improves the speed and precision of ion channel drug screening.
May accelerate ion channel drug screening; leaves open translation to cardiovascular therapeutics.
Population patch clamp (PPC) is a novel high throughput planar array electrophysiology technique that allows ionic currents to be recorded from populations of cells under voltage clamp. For the drug discovery pharmacologist, PPC promises greater speed and precision than existing methods for screening compounds at voltage-gated ion channel targets. Moreover, certain constitutively active or slow-ligand gated channels that have hitherto proved challenging to screen with planar array electrophysiology (e.g. SK/IK channels) are now more accessible. In this article we review early findings using PPC and provide a perspective on its likely impact on ion channel drug discovery. To support this, we include some new data on ion channel assay duplexing and on modulator assays, approaches that have thus far not been described.
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Dale et al. (2007) conducted a review in Ion channel drug discovery. Population patch clamp (PPC) vs. Existing methods for screening compounds was evaluated. Population patch clamp electrophysiology offers greater speed and precision than existing methods for screening compounds at voltage-gated ion channel targets in drug discovery.
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