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May 4, 2015Antimicrobial Agents and ChemotherapyOpen Access

Environmental Isolates of Azole-Resistant Aspergillus fumigatus in Germany

Oliver Bader Jana Tünnermann Anna Dudakova Marut Tangwattanachuleeporn Michael Weig Uwe Groß

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Abstract

Azole antifungal drug resistance in Aspergillus fumigatus is an emerging problem in several parts of the world. Here we investigated the distribution of such strains in soils from Germany. At a general positivity rate of 12%, most prevalently, we found strains with the TR34/L98H and TR46/Y121F/T289A alleles, dispersed along a corridor across northern Germany. Comparison of the distributions of resistance alleles and genotypes between environment and clinical samples suggests the presence of local clinical clusters.

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Bader et al. (2015) studied this question.

synapsesocial.com/papers/6a1de02a79ea62caf66037ce https://doi.org/10.1128/aac.00100-15

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