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A novel plain sedimentation technique for thrombus preparation in swine models produces mechanically stable, fibrin-rich clots histologically similar to human stroke thromboemboli, which may improve preclinical evaluation of thrombectomy devices.
We report the development of a novel technique of thrombus preparation for use in a swine model for evaluation of thrombectomy devices. The experimental thrombus prepared using plain sedimentation showed mechanical stability due to its solid fibrin-rich component. The thrombus also showed histologic similarity to the typical thromboemboli recovered from patients with stroke in the course of therapeutic thrombectomy. This new technique may be beneficial for preclinical evaluation of thrombectomy devices.
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Kan et al. (2010) studied this question.
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