NAD ⁺ repletion improves muscle function in muscular dystrophy and counters global PARylation

Dongryeol Ryu; Hongbo Zhang; Eduardo R. Ropelle; Vincenzo Sorrentino; Davi A. G. Mázala; Laurent Mouchiroud; Philip Marshall; Matthew D. Campbell; Amir S. Ali; Gary Knowels; Stéphanie Bellemin; Shama R. Iyer; Xu Wang; Karim Gariani; Anthony A. Sauve; Carles Cantó; Kevin E. Conley; Ludivine Walter; Richard M. Lovering; Eva R. Chin; Bernard J. Jasmin; David J. Marcinek; Keir J. Menzies; Johan Auwerx

doi:10.1126/scitranslmed.aaf5504

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may benefit patients with muscular dystrophies or other neuromuscular degenerative conditions characterized by the PARP/NNMT gene expression signatures.

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Ryu et al. (2016) studied this question.

synapsesocial.com/papers/6a1df1f5a44226b57c602328 https://doi.org/10.1126/scitranslmed.aaf5504

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NAD ⁺ repletion improves muscle function in muscular dystrophy and counters global PARylation

Abstract

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Cite This Study

NAD ⁺ repletion improves muscle function in muscular dystrophy and counters global PARylation

Abstract

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Discussion

Cite This Study

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