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Skin fibroblasts derived from patients with Down's syndrome (trisomy-21) have a significantly decreased number of cumulative cell population doublings (CPD) measured from the initial passage to senescence when compared with cultures from karyotypically normal age-matched controls (40 ± 1.5 vs 51.5 ± 2.0 CPD).
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Schneider et al. (1972) studied this question.
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