What does this research mean for the field?

Extreme physical exertion, such as completing a 99 km marathon, frequently induces myoglobinaemia that correlates linearly with serum urate and muscle enzymes, potentially contributing to acute renal failure. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1978QJM

Myoglobinuria, Rhabdomyolysis and Marathon Running

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Why the study?

Does completing a 99 km marathon cause myoglobinaemia and rhabdomyolysis in runners?

Population

44 runners completing a 99 km marathon

Design

Cohort

Authors

HSHarold B. SchiffTufts University EMEamonn T.M. MacSearraighAddington Hospital JKJeffrey C. KallmeyerSt Augustine College of South Africa

Discussion

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Implication

Marathon completion associates with myoglobinaemia and enzyme rises; hypothesis-generating for renal risk, needs prospective confirmation.

Structured PICO

Does completing a 99 km marathon cause myoglobinaemia and rhabdomyolysis in runners?

Population

44 runners completing a 99 km marathon

Intervention

Completing a 99 km marathon (exertion)

Outcome

Myoglobinaemia and levels of myoglobin, lactate, CPK, AST, and LDHsurrogate

Exertional rhabdomyolysis during a 99 km marathon leads to significant myoglobinaemia and elevations in muscle enzymes, which may contribute to acute renal failure.

Cite This Study

Schiff et al. (1978) studied this question.

synapsesocial.com/papers/6a1dfa91e30813deec34e27c https://doi.org/10.1093/oxfordjournals.qjmed.a067553

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Implication

Marathon completion associates with myoglobinaemia and enzyme rises; hypothesis-generating for renal risk, needs prospective confirmation.

Myoglobinuria, Rhabdomyolysis and Marathon Running

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myoglobinuria, Rhabdomyolysis and Marathon Running

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider