Does a BP goal of <130/80 mmHg improve outcomes in patients with chronic kidney disease?
The recommendation for a BP goal of <130/80 mmHg in CKD is based on observational data rather than randomized trials, highlighting the need for ongoing trials to establish its benefits and risks.
BP control is critical in the treatment of patients with chronic kidney disease. Recent guidelines now recommend a BP goal of <130/80 mmHg. Clinical trials using a randomized, intention-to-treat design have not established the benefits of this goal; rather, observational data and secondary or subgroup analyses drove the development of the new guidelines. A variety of observations suggest potential adverse events associate with achieving too low a BP in patients with chronic kidney disease, and ongoing randomized trials will have to establish the benefits or risks of meeting this goal.
Julia B. Lewis (Fri,) studied this question.