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Using an antiserum to synthetic ovine corticotropin-releasing factor (CRF), CRF-like immunoreactive neurons were observed in the central nervous system of normal and colchicine-treated rats. CRF immunoreactivity was observed in the hypothalamus, thalamus, amygdala, cerebral cortex, midbrain, pons medulla, cerebellum and spinal cord. The significance of the extrahypothalamic distribution of CRF-like immunoreactivity is unknown.
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Olschowka et al. (2008) studied this question.
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