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Recent archaeological investigations of Mississippian period (A.D. 1000–1400) sites permit the development of population estimates for an area immediately south of Cahokia, the largest prehistoric site in North America. Population estimates are derived from the number of structures at 11 sites, with the amount of prehistorically habitable land being incorporated as part of the estimating procedure. Population density increased somewhat during the earliest two of four Mississippian phases, reaching its peak during the Stirling phase. Thereafter, population decreased, reaching its lowest point during the Sand Prairie phase.
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George R. Milner (1986) studied this question.
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