A photocrosslinked micelle-hydrogel hybrid loaded with human dental pulp stem cells for cartilage defect repair

Puntos clave

• This research aims to evaluate the effectiveness of a micelle-hydrogel hybrid for repairing cartilage defects using human dental pulp stem cells.
• Developed a photocrosslinked micelle-hydrogel hybrid (GMKFM) for cartilage repair.
• Tested the hybrid for mechanical stability and sustained KGN release.
• Assessed the chondrogenesis of human dental pulp stem cells (hDPSCs) within the hybrid in vitro.
• GMKFM demonstrated mechanical stability and supported sustained release of KGN.
• hDPSCs-laden GMKFM significantly enhanced cartilage repair in a rat model.