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The aim is to create a detailed transcriptional atlas of mouse skeletal muscles using advanced sequencing techniques.

June 2, 20260 citationsOpen Access

Mouse Skeletal Muscle Atlas

Key Points

The aim is to create a detailed transcriptional atlas of mouse skeletal muscles using advanced sequencing techniques.
Utilized single-cell RNA sequencing and single-nucleus RNA sequencing technologies.
Performed transcriptome sequencing on various skeletal muscles of the mouse hindlimb.
Generated a comprehensive single-cell transcriptional atlas.
Constructed a detailed atlas of transcriptional profiles across multiple muscle types.
Identified specific gene expression patterns unique to each skeletal muscle.
Enhanced understanding of muscle diversity at the cellular level.

Abstract

Integrating single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq) technologies, we performed transcriptome sequencing on the skeletal muscles of the mouse hindlimb, including the quadriceps (QUAD), tibialis anterior (TA), extensor digitorum longus (EDL), gastrocnemius (GAS), and soleus (SOL). We further constructed a single-cell transcriptional atlas of distinct mouse skeletal muscles.

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