What question did this study set out to answer?

This case aims to describe the rare occurrence of progressive symmetric erythrokeratoderma in a patient with Down syndrome, which is not commonly reported.

June 2, 2026Open Access

A Rare Case of Progressive Symmetric Erythrokeratoderma in Down Syndrome

Key Points

This case aims to describe the rare occurrence of progressive symmetric erythrokeratoderma in a patient with Down syndrome, which is not commonly reported.
Detailed clinical evaluation of the patient presenting with PSEK.
Photographic documentation to illustrate the atypical presentation.
The patient exhibited symmetrical hyperkeratotic plaques primarily affecting the trunk, a rare finding.
No prior cases of PSEK associated with Down syndrome were identified in existing literature.

Abstract

Abstract Progressive symmetric erythrokeratoderma (PSEK) is an uncommon cornification genodermatosis characterized by symmetrical, erythematous, and hyperkeratotic plaques on the extremities. The trunk is usually spared, but palms and soles may be involved. A variety of cutaneous disorders have been reported with increased frequency in individuals with Down syndrome. Common cutaneous conditions with increased prevalence in Down syndrome are alopecia areata, acne, hidradenitis suppurativa, seborrheic dermatitis, infections, and ichthyosis. Occurrence of PSEK in association with Down syndrome has not been reported in the literature. We report a rare case of PSEK for its atypical presentation on the trunk and unusual association with Down syndrome.

A Rare Case of Progressive Symmetric Erythrokeratoderma in Down Syndrome

Key Points

Abstract

Cite This Study