Uncovering the “hidden” synaptic microarchitecture of the retinal direction selective circuit

This is the authors' abstract. We don't add key points for this paper.

imaging reveals that processing within local dendritic "DS subunits" is compromised when ACh dynamics are perturbed regionally with an acetylcholinesterase blocker. A network model that captures the specific anatomical "wiring" of the DS circuit reveals how minor perturbations in the spatiotemporal properties of ACh-that do not disrupt the global excitation/inhibition (E/I) balance-uncouple E/I locally and compromise direction selectivity. These results reveal the inner workings of the "hidden" synaptic microarchitecture that mediates diverse, localized direction computations across the DSGC's dendritic field.