Dual-responsive supramolecular self-assembly of inclusion complex of an azobenzene-ended poly(ε-caprolactone) with a water-soluble pillar[6]arene and its application in controlled drug release

Dual photo- and pH-responsive polymeric vesicles are constructed from a host–guest complex between a water-soluble pillar[6]arene and an azobenzene ended functionalized poly(ε-caprolactone). Reversible morphological transitions between vesicles and solid aggregates are achieved upon repeated UV stimulus and pH stimulus. Moreover, the polymeric vesicles present excellent cytocompatibility toward HepG2 cells and can be further applied for controlled release of a hydrophilic model drug, DOX•HCl.