Human female fat tissue from patients with endometrial carcinoma exhibits a higher rate of in vitro conversion of androstenedione to estrone compared to tissue from other patients.
The conversion of Δ4 to E1in vitro by human female fat tissue was investigated. In patients with endometrial carcinoma an average conversion of 0.1% was found. The values ranged from 0.03 to 0.19%. In the other patients this conversion was only 0.027 % with a range of 0.01 to 0.06 %. The significance of these results is discussed.
Schindler et al. (Sun,) studied this question.