What question did this study set out to answer?

To determine whether a tetranucleotide repeat polymorphism upstream (5′) of the human myelin basic protein gene is associated with susceptibility to multiple sclerosis.

January 29, 2009Acta Neurologica Scandinavica

A repetitive DNA sequence 5′ to the human myelin basic protein gene may be linked to MS in Danes

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Authors

SISolveig Nygaard IbsenRoskilde University JCJ. ClausenRoskilde University

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Implication

Case-control study reveals an association between a myelin basic protein repeat polymorphism and multiple sclerosis, suggesting genetic susceptibility linked to this locus.

Key Points

To determine whether a tetranucleotide repeat polymorphism upstream (5′) of the human myelin basic protein gene is associated with susceptibility to multiple sclerosis.
Conducted a case-control evaluation in 90 Danish patients with multiple sclerosis and 106 controls.
Isolated lymphocyte DNA and amplified the (TGGA)n repeat region 5′ to the MBP gene using PCR.
Separated PCR products via agarose and acrylamide gel electrophoresis to distinguish allele length variants.
Identified three distinct electrophoretic patterns: a 450 bp homozygote, a 375 bp homozygote, and a heterozygote containing both fragments.
Observed a significantly higher frequency of the 450 bp fragment and underrepresentation of the 375 bp fragment in multiple sclerosis patients versus controls (p < 0.01).

Cite This Study

Ibsen et al. (2009) studied this question.

synapsesocial.com/papers/6a1e7f7ac85b32e7cc55ef49 https://doi.org/10.1111/j.1600-0404.1996.tb00513.x

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Implication

Case-control study reveals an association between a myelin basic protein repeat polymorphism and multiple sclerosis, suggesting genetic susceptibility linked to this locus.

A repetitive DNA sequence 5′ to the human myelin basic protein gene may be linked to MS in Danes

Discussion

Member takes

Implication

Key Points

Cite This Study

A repetitive DNA sequence 5′ to the human myelin basic protein gene may be linked to MS in Danes

Discussion

Member takes

Implication

Key Points

Cite This Study

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