Isolated adult cardiac myocytes in suspension or culture serve as a useful model system for cardiotoxicity studies due to their retention of original properties and behavior under metabolic stress.
Isolated adult cardiac myocytes in suspension or culture serve as a useful and reliable model system for evaluating cardiotoxicity.
The preparation and properties of isolated adult cardiac myocytes are reviewed, with the goal being to evaluate their usefulness as a model system for measuring cardiotoxicity. Some important factors in cell isolation methodology which impact on the quality of the preparation are identified, along with criteria for assessing the quality of cells after isolation. By all criteria, myocytes isolated by good procedures appear to largely retain their original properties. Moreover, the distinctive behavior of adult myocytes under metabolic stress endows them with a particular usefulness as monitors of toxicity. Overall, we conclude that the art of adult heart cell isolation and culture is now sufficiently advanced for either freshly isolated cells in suspension or cells in culture to be a useful model system for toxicity studies.
Robert A. Haworth (Mon,) conducted a review in Cardiotoxicity. Isolated adult cardiac myocytes was evaluated on Usefulness as a model system for measuring cardiotoxicity. Isolated adult cardiac myocytes in suspension or culture serve as a useful model system for cardiotoxicity studies due to their retention of original properties and behavior under metabolic stress.