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July 1, 1975Proceedings of the National Academy of SciencesOpen Access

Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles.

Makoto Kimura Tatsuya Ota

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Abstract

A formula for the distribution of allelic frequencies in a finite population is derived assuming stepwise production of multiple alleles. Monte Carlo experiments were performed to check the validity of the formula, and excellent agreement was obtained between theoretical distribution and experimental results. The formula should be useful for analyzing genetic variability in natural populations that can be detected by electrophoretic methods.

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Kimura et al. (1975) studied this question.

synapsesocial.com/papers/6a1ea836989adebfe89a6a85 https://doi.org/10.1073/pnas.72.7.2761

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