Key result
Cardiovascular disease is linked to higher mean diffusivity in carotid vessel walls.
Why the study?
MR diffusion tensor imaging is feasible for evaluating carotid diffusivity, but its associations with cardiovascular disease, BMI, sex, and age in clinical settings needed identification.
Does two-dimensional vessel wall diffusion tensor imaging detect altered diffusivity associated with cardiovascular disease, age, sex, and BMI in human carotids?
Case-Control (n=38)
No
Does two-dimensional vessel wall diffusion tensor imaging detect altered diffusivity associated with cardiovascular disease, age, sex, and BMI in human carotids?
Two-dimensional vessel wall DTI of human carotids is feasible and can detect altered diffusivity associated with age, BMI, and cardiovascular disease, potentially serving as a marker for early-stage atherosclerosis and vascular ageing.
Answers are grounded in this paper and cite their sources.
May support DTI for detecting early vascular changes in CVD; hypothesis-generating and requires prospective validation.
BACKGROUND: Magnetic resonance (MR) diffusion tensor imaging (DTI) is a new, non-invasive method to investigate arterial vessel walls. High resolution diffusion weighted imaging (DWI) in combination with a two-dimensional (2D) diffusion gradient sampling scheme has recently been demonstrated as feasible for evaluating diffusivity in the vessel wall of human carotids. We aimed to identify associations of altered diffusivity in human carotids with presence or absence of cardiovascular disease, body mass index (BMI), sex and age in a clinical setting. METHODS: In this single center case-control study we used DWI in combination with a 2D gradient in a 3 T MRI scanner to evaluate diffusivity parameters in carotid vessel walls of clinical patients with known cardiovascular disease (n = 17) and healthy controls (n = 21). We used a read-out segmented EPI (rs-EPI) sequence for DWI. RESULTS: A group comparison showed significantly decreased fractional anisotropy (FA) in patients older than 60 years (p < 0.001) and in patients with a BMI higher than 25 (p = 0.019). Patients with cardiovascular disease had higher values for mean diffusivity (p = 0.005) than patients without cardiovascular disease. A multiple linear regression analysis showed age and sex to be associated with FA. CONCLUSION: Two-dimensional vessel wall DTI of human carotids is feasible for clinical research. Besides patient age, we identified Sex, BMI, or the presence of cardiovascular disease as relevant factors for carotid vessel wall diffusivity. Decreased FA values might indicate early-stage atherosclerosis and vascular ageing.
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Leber et al. (2025) conducted a case-control in Cardiovascular disease (n=38). Cardiovascular disease vs. Healthy controls was evaluated on Mean diffusivity and fractional anisotropy in carotid vessel walls (p=0.005). Cardiovascular disease was associated with higher mean diffusivity in carotid vessel walls (p=0.005), while age >60 years and BMI >25 were associated with decreased fractional anisotropy.
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