Meme kanseri nedeniyle radyoterapi uygulanan hastalarda Tp-e aralığı ve Tp-e/QT oranının prospektif olarak incelenmesi

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Breast cancer (n=51). Intervention: Adjuvant radiotherapy vs. Baseline (first day of RT). Primary outcome: Ventricular repolarization (Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio).

Q: What does this research mean for the field?

Adjuvant radiotherapy following systemic chemotherapy in breast cancer patients is associated with statistically significant increases in the Tp-e interval, indicating altered ventricular repolarization. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Necla Gürdal; Gizem Cosgun; Binnur Dönmez Yılmaz; Ahmet Gürdal

doi:10.47582/jompac.1302914

May 30, 2023Open Access

Meme kanseri nedeniyle radyoterapi uygulanan hastalarda Tp-e aralığı ve Tp-e/QT oranının prospektif olarak incelenmesi

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Why the study?

The study was conducted to investigate ventricular repolarization using the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio in breast cancer patients receiving adjuvant radiotherapy following chemotherapy.

Does adjuvant radiotherapy alter ventricular repolarization parameters (Tp-e interval, Tp-e/QT ratio) in breast cancer patients?

Study Design

Type

Observational (n=51)

Multicenter

No

Structured PICO

Does adjuvant radiotherapy alter ventricular repolarization parameters (Tp-e interval, Tp-e/QT ratio) in breast cancer patients?

P

Population

51 female postsurgical breast cancer patients (median age 62) treated with adjuvant doxorubicin/cyclophosphamide (AC) followed by weekly paclitaxel, with an indication for adjuvant radiotherapy. Key exclusions: neoadjuvant chemotherapy, HER2 positivity, coronary artery disease, arrhythmia, congenital heart disease, heart valve dysfunction, cardiomyopathy, dyslipidemia, history of myocardial infarction.

I

Intervention

Adjuvant radiotherapy (median dose 50 Gy) following systemic chemotherapy.

C

Comparator

Pre-radiotherapy baseline (electrocardiograms taken on the first day of radiotherapy).

O

Outcome

Ventricular repolarization changes measured by Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio on ECG at the end of radiotherapy.surrogate

Limitations

Patients received systemic chemotherapy before RT, which may affect ventricular repolarization
Inability to achieve complete homogenization in terms of age, menopause status, and BMI

Implication

Adjuvant radiotherapy in breast cancer patients acutely prolongs the Tp-e interval and increases the Tp-e/QT ratio, suggesting a potential early risk for ventricular repolarization abnormalities.

Abstract

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Discussion

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Cite This Study

Gürdal et al. (2023) conducted an observational in Breast cancer (n=51). Adjuvant radiotherapy vs. Baseline (first day of RT) was evaluated on Ventricular repolarization (Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio).

synapsesocial.com/papers/6a1ea8fee5c5a32e9d9a6cbb https://doi.org/10.47582/jompac.1302914

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Meme kanseri nedeniyle radyoterapi uygulanan hastalarda Tp-e aralığı ve Tp-e/QT oranının prospektif olarak incelenmesi

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Meme kanseri nedeniyle radyoterapi uygulanan hastalarda Tp-e aralığı ve Tp-e/QT oranının prospektif olarak incelenmesi

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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