Differential Analysis of Bilateral Mammograms

Computer support for early detection of breast cancer requires a proper mimicking of the way radiologists compare mammographic images; by comparing bilateral (images of the left and right breasts) and temporal images. In this paper, one method for bilateral registration and intensity normalization and two methods for difference analysis are described. The bilateral registration is based on anatomical features and assumptions of how the female breast is deformed under compression. The first method for differential analysis is based on the absolute difference between the registered images while the second method is based on statistical differences between properties of corresponding neighborhoods. The methods are tested on images from the MIAS database (on 100 images with 59 abnormalities distributed over four types) and evaluated by FROC-analysis. The performances of the two methods are similar but the statistical method gives better performance at a lower false positive rate and is better in particular for detecting asymmetrical developments.