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June 1, 1990Journal of Medicinal ChemistryOpen Access

Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site

Marcel Hibert Rémy D. Hoffmann Robert C. Miller Albert A. Carr

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Abstract

A conformation-activity relationship study of 5-HT3 receptor antagonists was used to define a pharmacophore and receptor map to qualitatively account for their activity. The design and synthesis of specific keto-amino-indole derivatives that are potent 5-HT3 receptor antagonists gave some support to the model.

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Cite This Study

Hibert et al. (1990) studied this question.

synapsesocial.com/papers/6a1eac03bf2a5d44faaf2a61 https://doi.org/10.1021/jm00168a011

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