Key result
Non-alcoholic fatty liver disease is associated with a procoagulant state, endothelial dysfunction, and platelet abnormalities that may induce progression of hepatic injury and cardiovascular disease.
Why the study?
NAFLD is strongly linked to cardiovascular disease and hypertension, which interfere with changes in the coagulation system dependent on liver damage severity.
NAFLD is a multisystem disease associated with a procoagulant state and endothelial dysfunction, highlighting the need to address cardiovascular and thrombotic risks in these patients.
Answers are grounded in this paper and cite their sources.
Supports CV/thrombotic risk assessment in NAFLD; leaves open whether targeting coagulation alters progression.
Non-alcoholic fatty liver disease (NAFLD) is closely related to insulin resistance, type 2 diabetes mellitus and obesity. It is considered a multisystem disease and there is a strong association with cardiovascular disease and arterial hypertension, which interfere with changes in the coagulation system. Coagulation disorders are common in patients with hepatic impairment and are dependent on the degree of liver damage. Through a review of the literature, we consider and discuss possible disorders in the coagulation cascade and fibrinolysis, endothelial dysfunction and platelet abnormalities in patients with NAFLD.
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Ogresta et al. (2022) conducted a review in Non-alcoholic fatty liver disease (NAFLD). Non-alcoholic fatty liver disease (NAFLD) was evaluated. Non-alcoholic fatty liver disease is associated with a procoagulant state, endothelial dysfunction, and platelet abnormalities that may induce progression of hepatic injury and cardiovascular disease.
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