Key result
Purified glucocorticoid hormone-receptor complex from rat liver binds specifically to the long terminal repeat sequences of cloned mouse mammary tumor virus DNA in a glucocorticoid-dependent manner.
Population
In vitro model using purified glucocorticoid hormone-receptor complex from rat liver and cloned mouse…
Comparison
Glucocorticoid hormone-receptor complex vs MMTV DNA lacking LTR sequences, pBR322, and…
Design
Preclinical
Authors
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Supports glucocorticoid receptor-DNA interactions in model systems; leaves open in vivo relevance and therapeutic translation.
This basic science study demonstrates that glucocorticoid hormone-receptor complexes bind specifically to the long terminal repeat of MMTV DNA, supporting the hypothesis that they regulate hormone-induced transcription near the start site.
Govindan et al. (1982) studied this question. Purified glucocorticoid hormone-receptor complex vs. DNA lacking LTR sequences / restriction fragments from pBR322 and phage lambda was evaluated on Specific binding to DNA sequences. Purified glucocorticoid hormone-receptor complex from rat liver binds specifically to the long terminal repeat sequences of cloned mouse mammary tumor virus DNA in a glucocorticoid-dependent manner.
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