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Many data structures (e.g., matrices) are typically accessed with multiple access patterns. Depending on the layout of the data structure in physical address space, some access patterns result in non-unit strides. In existing systems, which are optimized to store and access cache lines, non-unit strided accesses exhibit low spatial locality. Therefore, they incur high latency, and waste memory bandwidth and cache space.
Seshadri et al. (2015) studied this question.