High prevalence of medical conditions and unhealthy lifestyle behaviours in women with PCOS during preconception: findings from the Australian Longitudinal Study on Women’s Health

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Polycystic ovary syndrome (PCOS) during preconception (n=7966). Intervention: PCOS vs. Without PCOS. Primary outcome: Prevalence of obesity.

Chau Thien Tay; Deborah Loxton; Mahnaz Bahri Khomami; Helena Teede; Cheryce L. Harrison; Anju E. Joham

doi:10.1093/humrep/dead190

September 22, 2023Human ReproductionOpen Access

High prevalence of medical conditions and unhealthy lifestyle behaviours in women with PCOS during preconception: findings from the Australian Longitudinal Study on Women’s Health

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Key result

PCOS is linked to ~47% obesity prevalence during preconception, alongside increased depression, anxiety, and infertility.

n=7,966

Why the study?

Optimizing preconception health can improve maternal outcomes, but no study had examined preconception medical conditions and lifestyle behaviours in women with PCOS.

Study Design

Type

Cross-Sectional (n=7,966)

Multicenter

Yes

Structured PICO

P

Population

7,966 women aged 24-30 years from the Australian Longitudinal Study of Women's Health, including 942 women with PCOS and 7,024 women without PCOS.

C

Comparator

Women without PCOS

O

Outcome

BMI, pre-existing medical conditions, and modifiable lifestyle behaviours (including smoking, recreational drug use, alcohol intake, and physical activity level) during the preconception periodpatient reported

Main Result

Absolute Event Rate: 47.02% vs 22.33%

Women with PCOS have a significantly higher prevalence of obesity, depression, anxiety, and infertility during the preconception period compared to women without PCOS, highlighting the need for targeted preconception care and lifestyle interventions.

Limitations

The findings were based on self-reported data.
The cohort of women surveyed may have a higher level of education than women in the community, therefore our findings may underestimate the true prevalence of pre-existing medical conditions and lifestyle challenges faced by the broader population.
Findings were based on self-reported data
The cohort of women surveyed may have a higher level of education than women in the community, potentially underestimating the true prevalence of pre-existing medical conditions and lifestyle challenges

Implication

PCOS was associated with higher preconception obesity, depression, anxiety, and infertility; leaves open whether targeted interventions improve outcomes in this population.

Abstract

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Discussion

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Cite This Study

Tay et al. (2023) conducted a cross-sectional in Polycystic ovary syndrome (PCOS) during preconception (n=7,966). PCOS vs. Without PCOS was evaluated on Prevalence of obesity. Women with PCOS had a higher prevalence of obesity (47.02% vs 22.33%), depression, anxiety, and infertility during preconception compared to women without PCOS.

synapsesocial.com/papers/6a1ebb1c94615786b59a7841 https://doi.org/10.1093/humrep/dead190

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High prevalence of medical conditions and unhealthy lifestyle behaviours in women with PCOS during preconception: findings from the Australian Longitudinal Study on Women’s Health

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

High prevalence of medical conditions and unhealthy lifestyle behaviours in women with PCOS during preconception: findings from the Australian Longitudinal Study on Women’s Health

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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