Arterial stiffness was independently and inversely associated with lumbar spine bone mineral density in healthy women (r=-0.229, P=0.015), but this association was not statistically significant in men.
Cross-Sectional (n=239)
No
Is there an independent association between arterial stiffness and bone mineral density in healthy men and women?
Arterial stiffness is independently associated with lower bone mineral density in women, but this association is not statistically significant in men.
Effect estimate: r=-0.229
p-value: p=0.015
BACKGROUND: Association of arterial stiffness and osteoporosis has been previously reported in women. However, this association is still controversial for men. Therefore, we investigated correlation of arterial stiffness and osteoporosis by measuring brachial-ankle (ba) pulse wave velocity (PWV) and bone mineral density (BMD). METHODS: We reviewed medical charts of 239 people (women: 128, men: 111) who visited the Health Promotion Center, retrospectively. ba-PWV was measured by automatic wave analyzer. Lumbar spine (L1-L4) BMD and femur BMD were measured by dual energy X-ray absorptiometry. Metabolic syndrome was based on the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATPIII) definition. Body mass index (BMI)>25 kg/m(2) was used instead of waist circumference. RESULTS: In Pearson's correlation analysis, PWV and femur BMD (Neck, total) had a significant inverse relationship in men (r=-0.254, P=0.007; r=-0.202, P=0.034). In women, PWV and the L-spine, femur (Neck, total) had a significant inverse relationship. (r=-0.321, P<0.001; r=-0.189, P=0.032; r=-0.177, P=0.046) Age and PWV showed the greatest association in both men and women (r=0.46 P<0.001; r=0.525, P<0.001) In multiple regression analysis, the L-spine BMD and PWV had an independent relationship in women after adjusting for age, metabolic syndrome, BMI, smoking, drinking and exercise. (r=-0.229, P=0.015). No independent association was found between PWV and BMD in men. CONCLUSIONS: The association between arterial stiffness and BMD was confirmed in women. However, this association was not statistically significant for men.
Kim et al. (Wed,) conducted a cross-sectional in Healthy (n=239). Arterial stiffness (ba-PWV) was evaluated on Independent correlation between brachial-ankle pulse wave velocity and lumbar spine bone mineral density in women (r=-0.229, p=0.015). Arterial stiffness was independently and inversely associated with lumbar spine bone mineral density in healthy women (r=-0.229, P=0.015), but this association was not statistically significant in men.
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