Women aged 60 to 70 years were 96% more likely than men to develop incident Alzheimer's disease dementia (HR 1.96), whereas no significant sex difference was observed in adults over 70.
Cohort (n=1,398)
No
Do sex and baseline biomarkers affect the risk of incident Alzheimer's disease and memory decline in older adults?
Women aged 60-70 have a significantly higher risk of incident Alzheimer's disease compared to men, and lower plasma Aβ42 is associated with faster memory decline specifically in women, suggesting sex-specific pathological pathways in early-stage AD.
Hazard Ratio: 1.96 (95% CI 1.08–3.56)
valor p: p=0.027
Abstract Background Sex differences in Alzheimer's disease (AD) are not well understood. Methods We performed sex‐specific analyses of AD and annualized cognitive decline with clinical and blood biomarker data in participants 60+ years old in the community‐based longitudinal Framingham Heart Study Offspring Cohort ( n = 1398, mean age 68 years, 55% women). Results During 11 years of follow‐up, women were 96% more likely than men to be diagnosed with clinical AD dementia after adjusting for age and education in the younger age group 60 to 70 years ( n = 946; 95% confidence interval CI, 1.08 to 3.56) although not in the older age group (70+) ( n = 452; hazard ratio = 0.98; 95% CI, 0.68 to 1.53). Sex‐differences in incident AD rates decreased with increasing levels of education. The total contribution of the biomarkers to AD risk variance was 7.6% in women and 11.7% in men. One unit (pg/ml) lower plasma Aβ42 was associated with 0.0095 unit faster memory decline in women ( p = 0.0002) but not in men ( p = 0.55) after adjusting for age and education. Discussion Our study suggests that both early life and later‐life pathological factors may contribute to potential sex differences in incident AD.
Liu et al. (Sat,) conducted a cohort in Alzheimer's disease (n=1,398). Female sex vs. Male sex was evaluated on Incident clinical Alzheimer's disease dementia (age 60-70 years) (HR 1.96, 95% CI 1.08 to 3.56, p=0.027). Women aged 60 to 70 years were 96% more likely than men to develop incident Alzheimer's disease dementia (HR 1.96), whereas no significant sex difference was observed in adults over 70.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: