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Multisystem inflammatory syndrome in children (MIS-C) is a recently described systemic inflammatory sequelae of SARS-CoV-2 infection. Diagnostic criteria for MIS-C includes age 38°C), laboratory evidence of inflammation, clinically severe illness requiring hospitalization with multisystem (≥2) organ involvement, Evidence of current or recent SARS-CoV-2 infection or exposure, and has no alternative explanation for their symptoms. We present a 15-year-old, morbidly obese male whose diagnosis of MIS-C was obfuscated by diabetic ketoacidosis (DKA). This case highlights the increased risk of development of MIS-C in obese children, variability of presentation, and contributes to the body of research demonstrating endocrinologic complications of MIS-C.
Tumberger et al. (2026) studied this question.