Computational modeling of rabbit ventricular and Purkinje cells provides a framework to study arrhythmogenic behavior and APD dispersion in short QT syndrome.
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Provides computational framework for APD dispersion in short QT syndrome; extends rabbit Purkinje-ventricular models but leaves human translation open.
Remarkable differences in action potential properties between the Purkinje fibre and ventricular cells may lead to abnormalities in excitation conduction through the Purkinje-ventricular junction (PVJ) and arrhythmogenic behaviour. We develop a family of electrophysiologically detailed computer models for rabbit epicardial, midmyocardial and endocardial ventricular myocytes, as well as the rabbit Purkinje fibre cells, in order to simulate a realistic APD dispersion during conduction through the PVJ under normal conditions and under pathological conditions of the short QT syndrome associated with HERG N588K mutation.
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Aslanidi et al. (2007) studied this question.
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