The Journal of the American Medical Association

535Dearborn Avenue... Chicago, Ill. Cable Address.... "Medic, Chicago" Subscription price.....Five dollars per annum in advance [For other information see second page following reading matter] SATURDAY, NOVEMBER 18, 1911 THE CULTIVATION OF THE SPIROCHÆTA PALLIDA During the past decade remarkable advances have been made in the placing of the pathology of syphilis on a sound basis. In 1903, Metchnikoff and Roux first demonstrated the experimental production of the disease by animal inoculation; two years later Schaudinn and Hoffmann announced the discovery of theSpirochœta pallida, since conceded to be the etiologic agent of the disease; and in 1906 Wassermann, Neisser and Bruck published the method of serum diagnosis with which we associate their names. Schaudinn and Hoffmann gave excellent descriptions of the morphology of theSpirochœta pallidaand detailed methods of demonstrating the organism in the secretions and in the tissues of syphilitic lesions. Many observers confirmed their observations, but,