A trial was undertaken to convert patients who were habitual users of barbiturates or Mandrax to flurazepam. This was accomplished in 45 of the 57 patients (78·9°) within a period of 2 to 5 weeks. Three typical case histories are given. The flurazepam was well tolerated and apart from the metallic taste reported by four patients, no other side-effects were reported.
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MacPhail et al. (1975) studied this question.